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Author

Nicole A. Cheung

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Open access Aug 2026

A two-factor authentication mechanism licenses pilins for pilus assembly in gram-positive bacteria.

A "two-factor authentication" mechanism for pilus assembly in gram-positive bacteria is defined: class C sortases first verify pilin identity by forming a membrane-embedded interface that activates the enzyme, then they recognize the LPXTG motif to initiate loading and crosslinking.

Nicole A. Cheung, Reece M. Pawlaczyk, Brendan J. Mahoney et al. · 0 citations

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