Nicole Teixeira

PCA-mapping and machine learning identify multiple chemotypes with antiplasmodial, β-haematin and haemozoin formation inhibition activity

Inhibiting the formation of haemozoin remains a robust, non-genomic target for antiplasmodial drug discovery. While current efforts focus on multistage active compounds that are not pure haemozoin formation inhibitors, this class offers advantages including selectivity for Plasmodium and is associated with lowered resi...