Aug 2026
Pharmacological inhibition of CDK7 and CDK9 suppresses gastrointestinal (colon) cancer progression through modulation of stemness, epithelial-mesenchymal transition, and chemoresistance.
GNE-3511 exerts potent anticancer activity by disrupting CDK7/9-dependent transcriptional programs that regulate proliferation, apoptosis, stemness, EMT, and multidrug resistance and is identified as a potential lead candidate for the treatment of colorectal cancers.
Nidhi Sharma, Suriya Panneerselvam, Sandip B. Bharate et al.
· Naunyn-Schmiedeberg's Archiv... · 0 citations