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Nien-Pei Tsai

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Open access Sep 2026

ATF4 Modulates Group 1 mGluR-Dependent molecular signaling, hippocampal plasticity and behavior.

Group 1 metabotropic glutamate receptors (Gp1 mGluRs) are critical effectors in behavior. Abnormal Gp1 mGluR signaling is frequently observed in neurodevelopmental and cognitive disorders. It is established that activation of Gp1 mGluR elicits translation-dependent neuronal plasticity mechanisms, such as long-term syna...

Shi-Yu Wang, Yeeun Yook, Simon Lizarazo et al. · 0 citations
Open access Oct 2026

Hyperfunction of PSD-95 leads to hyperexcitability and cognitive abnormalities in MEF2C haploinsufficiency.

Myocyte enhancer factor 2C (MEF2C) is a transcription factor critical for brain circuit development and cognitive behavior. The loss of one copy of MEF2C leads to MEF2C haploinsufficiency syndrome (MCHS), a neurodevelopmental disorder characterized by intellectual disability, epilepsy, and behavioral phenotypes associa...

Mei-Jin Pan, Anirudh R. Acharya, Kwan Lee et al. · 0 citations
Open access Aug 2026

Spatially varying gene regulation network inference from spatial transcriptomics

Applications to seqFISH mouse embryo data and Visium human cutaneous squamous cell carcinoma and fallopian tube datasets demonstrate that SVGRN captures spatially varying regulatory programs underlying development, tumor progression, and tissue organization, highlighting its robustness and broad applicability.

Yu-Rui Li, Jin Y. Chen, Ting Lu et al. · 0 citations

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