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Nikolaos P. Tzavellas

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Review Open access Sep 2026

Revising NHE‐1: From Cardiac Homeostasis to Heart Failure and Future Drug Development

NHE‐1 is a Na+/H+ exchanger that receives phosphorylation signals, binds calmodulin and responds to neurohormonal input from angiotensin II, endothelin‐1, and adrenergic pathways. In cardiac myocytes, NHE‐1 maintains pH homeostasis and couples to Na+/Ca2+ exchange and mitochondrial ion handling. During heart disease su...

V. Bouratzis, Nikoleta Douskou, Nikolaos P. Tzavellas et al. · 0 citations

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