Structure-Guided Development of Selective HDAC4 and HDAC7 Inhibitors That Modulate Th17 Cell Transcription.
Class IIa histone deacetylases (HDACs) are attractive therapeutic targets due to their specialized regulatory functions and restricted expression patterns. Recent studies identified HDAC4 and HDAC7 as critical regulators of Th17-cell differentiation, acting through distinct transcriptional mechanisms to promote Th17 li...