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Niloofar Yousefi

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Review Open access Aug 2026

From rules to foundation models: a comprehensive review of machine learning approaches for siRNA design

Abstract Small interfering RNAs (siRNAs) are a clinically validated therapeutic modality with eight FDA-approved drugs, yet designing effective siRNAs remains computationally challenging due to complex dependencies on sequence composition, thermodynamic properties, target-site accessibility, and off-target interactions...

Zahra Khodagholi, Niloofar Yousefi · 0 citations

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