Author

Nils Lorz

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Open access Sep 2026

Terazosin Activates or Inhibits Human Phosphoglycerate Kinase 1 on a Dose-Dependent Basis: Mechanistic and Structural Insights by NMR

Phosphoglycerate kinase 1 (PGK1) is a key metabolic enzyme responsible for ATP production, and its dysregulation is linked to the Warburg effect in cancer and to neurodegenerative diseases such as Parkinson’s. Recent studies indicate that terazosin, an FDA-approved drug, enhances PGK1-mediated ATP production. However...

M. Bütikofer, Felix Torres, Dhiman Ghosh et al. · JACS Au · 0 citations

Open access Jul 2026

A Comprehensive 19F NMR Framework for Fragment-Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR.

The design and validation of a non-proprietary 19 F NMR screening library (OpenFL600) capable of probing diverse binding pockets, as demonstrated for RNA, G protein-coupled receptors, kinases, protein-protein interactions, and proteases is presented.

S. Rüdisser, Gabriela R. Stadler, G. Padroni et al. · Angewandte Chemie · 0 citations