Nina G. Steele

HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α

Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis.

BACKGROUND AND AIMS The tumor microenvironment drives many malignant features of pancreatic ductal adenocarcinoma (PDAC). The fibroblasts within pancreatic tumors promote tissue remodeling, immune suppression, and resistance to therapy. However, the interactions between stromal populations and pancreatic cancer cells a...

Abstract B031: Spatial profiling reveals distinct tumor and myeloid ecosystems across lung and liver metastases in pancreatic ductal adenocarcinoma

The findings reveal distinct metastatic microenvironments in liver and lung characterized by coordinated differences in tumor subtype composition and myeloid phenotype, highlighting the importance of local immune landscapes in shaping metastatic disease biology.

Abstract B011: HMGA2 controls fibroblast skewing and immune infiltration in basal pancreatic cancer

The role of tumoral HMGA2 expression in controlling an immunosuppressive TME is demonstrated, a potential biomarker to determine TME phenotype in PDAC patients is highlighted and a novel subtype-specific immunomodulatory therapy is introduced.