Zika Virus NS3 Drives the Assembly of a Replication Compartment-like Structure That Exerts the Structural and Physiological Functions of the Viral Replication Compartment
It is shown that the ZIKV non-structural protein 3 (NS3), a dual-function protease and RNA helicase, is sufficient to drive the assembly of a replication compartment-like structure (RCLS) in human cells, and that the helicase domain and not the protease domain is required for optimal RCLS formation and organelle recrui...