Sepsis is a systemic vascular disorder in which endothelial activation, dysfunction, and structural injury contribute to shock, microcirculatory failure, immunothrombosis, and multiorgan dysfunction. Sepsis-associated endotheliopathy is not a uniform process but a dynamic trajectory that evolves from adaptive endotheli...
Song Qin, Ni-Nan Dai, Feng-Yun Xu et al.· Journal of Clinical Investig...· 0 citations
The locus coeruleus (LC) is the primary source of noradrenergic (NE) neurons in the central nervous system, with extensive neural projections throughout the brain, serving as a key ascending modulatory center for regulating cognitive functions. In recent years, the advances in optogenetics, chemogenetics, and high-reso...
Xue Li, Xiaoli Liang, Xinyu Yuan et al.· Frontiers in Human Neuroscie...· 0 citations
Overall, MOTS-c represents a plausible but insufficiently validated molecule in SICM research, and its translational relevance will depend on disease-specific mechanistic and pharmacological validation.
Ze-Ze Zhao, Wei Chen, Xiaoqian Zheng et al.· European Journal of Pharmaco...· 0 citations
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