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Author

Ning-Hang Ruan

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Open access Sep 2026

ROS-responsive biomaterial delivery of the TCM-derived small molecule coptisine protects stem cells and attenuates intervertebral disc degeneration

Oxidative stress compromise nucleus pulposus-derived mesenchymal stem cells (NPMSCs) and restrict endogenous repair in intervertebral disc degeneration (IDD). Here, human nucleus pulposus (NP) tissues showed that secreted phosphoprotein 1 (SPP1) expression increased with degeneration severity. Screening of 2,987 trad...

Shou-Yun Xiao, Ning-Hang Ruan, Bi-Jun Wang et al. · 0 citations

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