Oct 2026
Design and structure-activity relationship studies of marine-derived indolocarbazoles as potent PIM1 inhibitors for triple-negative breast cancer therapy.
PIM1 has emerged as a compelling target for triple-negative breast cancer (TNBC), which lacks effective treatments. Through integrated virtual screening and in vitro validation, N6 was identified as a potent PIM1-active indolocarbazole lead, although its strong PKC inhibition indicated a limited selectivity window. Str...
Yun Huang, Yi-Jun Ma, Jie-Bin Fang et al.
· Bioorganic chemistry (Print) · 0 citations