Ischemic stroke (IS) is a severe central nervous system disorder with high mortality and disability rates, and microglia-mediated neuroinflammation exacerbates ischemic brain injury. In this study, the traditional ethnic medicine Rhaponticum repens (L.) Hidalgo was found to significantly inhibit lipopolysaccharide (LPS...
Ye-Wen Jia, Wen Dang, Jia-Yi Du et al.· Bioorganic chemistry (Print)· 0 citations
Mechanistic studies and in vivo experiments demonstrated that intravenous injection of compound B3 could achieve prominent therapeutic efficacy with a high safety profile and indicate that compound B3 is a promising candidate for CRC treatment.
Ye Zhong, Jing Xu, Lian-Zhe Zhang et al.· European journal of medicina...· 0 citations
The pharmacological effects, biosynthetic pathways, and biomanufacturing methods of different types of coumarins are reviewed, providing important references for the green, efficient, and sustainable production of coumarins, and are conducive to promoting the development of new coumarin-based drugs.
Wang-Bin Chen, Jia-Zeng Yang, Ning Li et al.· Zhongguo Zhong yao za zhi =...· 0 citations
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