Open access
Aug 2026
Slitrk5 deficiency preserves reversal learning but alters orbitofrontal-striatal signaling and task-related responding in mice.
Obsessive-compulsive disorder (OCD) is a debilitating condition associated with repetitive behaviors and cognitive inflexibility, often linked to abnormalities in cortico-striato-thalamo cortical (CSTC) circuitry. Although the Slitrk5 knockout (Slitrk5-/-, KO) mouse has been proposed as an OCD-related model, it remains...
Ole Borup Svendsen, Hui Shi, Humam Ahmed Hamdoun et al.
· Behavioural Brain Research · 0 citations