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Review Open access Sep 2026

Neural Remodeling Shapes a Nerve-Dependent Metastatic Ecosystem in Ovarian Cancer.

Ovarian cancer (OC) remains a highly lethal malignancy characterised by diffuse peritoneal dissemination and frequent treatment resistance. Beyond tumor-intrinsic alterations and classical stromal support, the peripheral nervous system is emerging as an important component of the tumor microenvironment. Here, we develo...

Li Ou, Chen-Zhao Feng, Chen Sun et al. · 0 citations
Review Open access Sep 2026

Targeting cancer-associated fibroblasts: therapeutic strategies, translational challenges, and future perspectives

Cancer-associated fibroblasts (CAFs) act as key drivers of cancer progression and therapeutic resistance within the tumor microenvironment, but their diverse and context-dependent functions complicate therapeutic targeting. The limited clinical efficacy of CAF-targeting therapeutics has prompted a critical reassessment...

Yan-Ping Jiang, Bo Ding, Han Yin et al. · 0 citations

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