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Ning-Ning He

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Open access Sep 2026

Stachyose supplementation attenuates ischemic stroke injury via gut-brain axis mediated adenine metabolism and neuroactive ligand-receptor signaling

Collectively, STA may exert neuroprotective effects in stroke by regulating gut microbiota-associated metabolites and subsequently modulating the neuroactive ligand-receptor interaction signaling pathway, thereby mediating crosstalk along the gut-brain axis.

Zi-Chen Zhang, Hao-Yan Zhang, Xue-Ying Liu et al. · 0 citations
Open access Sep 2026

Bacteroides cellulosilyticus-derived 2-hydroxyphenylacetic acid rectifies hepatic lipid homeostasis in MASLD by targeting the PPARγ-CD36 axis

The mechanism by which B. cellulosilyticus and 2HPAA alleviate MASLD by targeting the PPARγ-CD36 pathway is revealed, providing a new perspective for the study of gut microbiota-host interactions in regulating liver diseases.

Kaiwei Chen, Zizhen Yang, Ji-Xing Peng et al. · 0 citations
Aug 2026

Pectic oligosaccharides reshape the gut microbiota-mediated intestinal vitamin B7 metabolic network to alleviate metabolic dysfunction-associated steatotic liver disease.

This study identified POS as an effective intervention to alleviate MASLD by restoring intestinal endogenous VB7 supply, providing a strong rationale for developing POS as a therapeutic prebiotic.

Zizhen Yang, Yujia Fu, Shuhan Liu et al. · 0 citations

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