Oct 2026
Fungal Phosphatase-Dependent Induction of Host Cell Pyroptosis by Candidalysin
It is shown that candidalysin, the cytolytic peptide toxin of Candida albicans, induces cell type-specific pyroptosis in epithelial cells and macrophages through GSDME and GSDMD activation, respectively, and that PHO100-mediated phosphate regulation contributed to fungal growth and hyphal development under phosphate li...
Yue-Mei Hong, Xiu-Li Wang, Lu Wang et al.
· ACS Infectious Diseases · 0 citations