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Ning-Ning Zhang

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Open access Sep 2026

A ketogenic enzyme HMGCS2 drives malignant progression in HER2-negative breast cancer via RAB23-mediated β-catenin/TCF signaling and mediates Apatinib resistance.

BACKGROUND 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme of ketogenesis. However, its role in breast cancer progression and drug resistance beyond metabolic regulation remains poorly understood. This study investigates the oncogenic function and resistance-promoting mechanism of HMGCS2...

Jing Wu, Mei Liu, Wei Li et al. · 0 citations

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