Author

Ning Tang

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Review Open access Sep 2026

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

ABSTRACT Cyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric...

Liang Yan, Si-Yi Liu, Yan-Ling Li et al. · Cancer Medicine · 0 citations

Review Open access Aug 2026

The Bidirectional Role of Cellular Senescence in the Treatment of Ovarian Cancer

This review systematically examines the intricate regulatory network of cellular senescence, encompassing multiple pathways including telomere dysfunction, DNA damage response, epigenetic remodeling, hormone signaling, and metabolic reprogramming, and integrating such strategies with conventional therapies holds promis...

Didi Yuan, Mengying Chen, Jinmei Wei et al. · Biomedicines · 0 citations