Open access
Aug 2026
FBXW5 blunts RIGI/MDA5/IFN signaling to drive immune evasion and chemo-immune resistance in triple-negative breast cancer models
These findings establish FBXW5 as a master regulator of the “cold” TME, presenting a potential predictive biomarker and actionable therapeutic target for enhancing chemoimmunotherapy in TNBC.
Xin Li, Tong Chen, Wen-Jing Zhao et al.
· Journal of Clinical Investig... · 0 citations