Disease-associated missense mutations are well known to affect protein turnover by either impairing substrate-ubiquitin ligase interactions or inducing misfolding-triggered protein clearance. Whether such mutations can drive gain-of-function in substrate-selective protein degradation remains under-explored. Here, we de...
Bai-Yun Wang, Chi-Wei Yeh, Hsuan-Mei Lin et al.· bioRxiv· 0 citations
It is shown that SA stabilizes the SA-binding domain of NPR1 and allosterically promotes its interaction with MED15A, a subunit of the Mediator complex, which provides a mechanistic resolution to the longstanding question of how SA promotes transcriptional activation during plant immune responses.
Song-Wen Zhang, Madeline Gish, Huan Li et al.· Nature· 0 citations
It is found that affinity governs the phase boundary, resistance to chemical perturbation, and molecular mobility of condensates in vitro and in human cells and is shown to be a quantitative determinant of condensate phase behavior, internal dynamics and biochemical output.
Andres Reyna, Madyson O. Briggs, Alexander F. Russell et al.· bioRxiv· 0 citations
It is proposed that the FOXA1-PBX1 complex could represent a higher-order regulatory node integrating chromatin accessibility and ER-driven transcriptional output, and functional enrichment analyses showed strong convergence on coherent biological pathways.
