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Author

Nirav Dhanesha

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2 papers indexed here

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Open access Sep 2026

Targeting lipidated amino acid deficiency mitigates fibrosis via a PPARα/CCL2 axis in metabolic dysfunction-associated steatohepatitis models.

Metabolic dysfunction-associated steatohepatitis (MASH) is rising globally despite recent therapeutic advances, highlighting the need to identify new targetable pathways. While dysregulated lipid and amino acid metabolism are established features of MASH, the interplay between these two metabolic pathways remains unexp...

S. Anand, Sandeep Das, Fabio Arias et al. · 0 citations
Open access Sep 2026

A Synthetic, Small Molecule, Allosteric Inhibitor of Human Factor XIa for Thrombosis.

Only a handful of anticoagulants have reached the clinic to treat and prevent thrombotic episodes in the millions of patients suffering from cardiovascular, cancer, viral (COVID-19) and metabolic diseases. In this work, we report the discovery, chemical synthesis, mechanistic biochemistry, pharmacology, and toxicology...

Chiranjeev Sharma, Rama Gunta, Sridhar R. Iyer et al. · 0 citations

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