A luciferase-based high-throughput three-dimensional tumor spheroid model identifies a renieramycin T derivative with anti-cancer stem cell activity in non-small cell lung cancer.
Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to therapeutic resistance and tumor recurrence. In non-small cell lung cancer (NSCLC), cancer stem cells (CSCs) have emerged as key contributors to tumor persistence and progression. However, accelerated CSC-targeted drug discovery...