Author

Noah A. Nutter

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Open access Sep 2026

DksA-dependent stringent stress response drives virulence and gastrointestinal persistence of Klebsiella pneumoniae

ABSTRACT Successful gastrointestinal (GI) colonization by bacterial pathogens requires adaptation to nutrient competition and host-derived stresses in the gut, with adaptation via the bacterial stringent stress response playing a critical role. Epidemiological data suggest that the GI tract serves as a reservoir from w...

Md. Maidul Islam, Robert L. Beckman, Noah A. Nutter et al. · Infection and Immunity · 0 citations

Open access Sep 2026

Influenza A virus co-infection alters Streptococcus pneumoniae gene expression during upper respiratory tract colonization

ABSTRACT Streptococcus pneumoniae (Spn) asymptomatically colonizes the upper respiratory tract (URT), a niche from which it can transmit to another host or cause invasive disease in the same host. The in vivo transcriptional adaptations that Spn undergoes during nasopharyngeal colonization, particularly during influenz...

Noah A. Nutter, A. Costa-Terryll, Lance M. Miller et al. · Infection and Immunity · 0 citations

Open access Sep 2026

DksA-dependent stringent stress response drives virulence and gastrointestinal persistence of Klebsiella pneumoniae

Using a murine model, DksA is established as a central integrator of the stringent response, coordinating membrane stress resistance, virulence traits, and gastrointestinal colonization in K. pneumoniae.

Md. Maidul Islam, Robert L. Beckman, Noah A. Nutter et al. · Infection and Immunity · 0 citations