Nompumelelo Anna-Cletta Gumede

Investigating the effect of diet-induced prediabetes on the HPA-axis, sympathetic nervous system and endogenous opioids in male Sprague-Dawley rats

Prediabetes is associated with metabolic dysfunction that may disrupt neuroendocrine regulation before the onset of overt type 2 diabetes mellitus. Although previous studies have independently examined alterations in the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic nervous system (SNS), and endogenous opi...