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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Nooshin Khoshdoozmasouleh

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Review Open access Oct 2026

A guide to studying tumour-T-cell interactions using in vitro coculture assays.

T cells are central mediators of antitumour immunity and are the cellular basis of many successful cancer immunotherapies, including immune checkpoint blockade, T-cell receptor (TCR)-engineered therapies and chimeric antigen receptor (CAR) T cells. However, clinical responses remain variable, and many tumours evade or...

Nooshin Khoshdoozmasouleh, Conor J. Kearney · 0 citations
Open access Aug 2026

An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted Therapy

BRAF mutant colorectal cancer (CRC) remains difficult to treat despite the clinical use of combined BRAF and EGFR inhibition, highlighting a need to define tumour-intrinsic mechanisms that limit therapeutic response. Here, using genome-wide CRISPR-Cas9 screening in BRAF-mutant CRC cells, we identify MEN1, encoding the...

Akash Srivaths, Aleen Al Halawani, Tirta M. Djajawi et al. · 0 citations

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