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Author

Norbert Donhause

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Jul 2026

Antagonistic regulation of HBZ splicing by hnRNPA1 and hnRNPH1 drives HTLV-1 leukemogenesis

It is established that HBZ inhibits hnRNPA1 transcription, therefore allowing HTLV-1 to hijack host RNA splicing and to generate an oncogenic isoform that drives transformation and chemoresistance and position HBZ splicing and its regulators as therapeutic targets in ATL.

Julie Tram, Célima Mourouvin, Laetitia Marty et al. · 0 citations