Author

Noriko Saitoh

2 papers indexed here

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Open access Oct 2026

Contribution of Topoisomerase IIα chromatin-tether and C-terminal domain to mitotic chromosome association and structural organization.

Mitotic functions of Topoisomerase IIα (TopoIIα) are dictated by its C-terminal domain (CTD), which is distinct from TopoIIβ. The chromatin-tether domain (ChT) within the αCTD recognizes methylated chromatin, an ability lacking for TopoIIβ and loss of αChT leads to ultrafine DNA bridges (UFBs) and chromosome bridges in...

B. Lama, Sanjana Sundararajan, A. Saraf et al. · Journal of Cell Science · 0 citations

Open access Sep 2026

Repeat element–anchored enhancer–promoter interactions (REEPIs) shape the regulatory landscape of hormone-resistant breast cancer

These findings reveal a repeat-guided regulatory architecture associated with transcriptional adaptation in endocrine resistance and identify REEPIs as a previously underexplored component of regulatory reprogramming in hormone-resistant breast cancer.

Xu-Feng Shu, Sheng-Lian Ni, M. Murata et al. · bioRxiv · 0 citations