Open access
Sep 2026
Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain
Structural studies of amyloid fibrils extracted from brain tissue have identified disease-specific fibril polymorphs. However, the mechanisms driving distinct polymorphs remain unclear because no method currently links the cellular context, composition and ultrastructure of individual aggregates to their constituent fi...
Lukas van den Heuvel, Daniel A. Stähli, Julika Radecke et al.
· bioRxiv · 0 citations