HLA-E-restricted KIR+ CD8+ regulatory T cells are enriched during allograft rejection and suppress activated CD4+ T cells in vitro and ex vivo 2308005
CD8+T cells expressing NK cell receptors have regulatory function. We have shown that alloreactive CD4+T cells upregulate Qa-1 (human HLA-E) stress-peptide complex in mice, enabling elimination by Qa-1—restricted Ly49+CD8+Tregs and promoting graft survival. We hypothesized that analogous human CD8+Tregs exist, ex...