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Author

Nunzio Perta

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Open access Sep 2026

A selective JNK3-targeting miniprotein confers neuroprotection in a mouse model of ischemic stroke

Ischemic stroke remains a leading cause of death and long-term disability, and current reperfusion therapies do not prevent progressive neuronal loss and neurological decline. Thus, therapeutic strategies targeting intracellular pathways underlying post-ischemic neurodegeneration remain a critical unmet clinical need...

Nunzio Perta, Stefano Fumagalli, C. Villani et al. · 0 citations
Open access Jul 2026

Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons

Mapping the spatiotemporal dynamics of PS exposure in mature hippocampal neurons under physiological and pathological conditions using time-lapse imaging reveals specific PS externalization hotspots at dendritic branching points, presenting a potential target for neuroprotective strategies in neurodegeneration.

Adriana Schneider, Alexandra B. Merkel, Nunzio Perta et al. · 0 citations

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