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It is shown that many popular imputation algorithms systematically fail under structured missingness, distorting the underlying statistical properties of the data in ways that conventional accuracy metrics cannot detect.
Our understanding of the genetic architecture of obesity is primarily based on studies of adults, with sparser data from childhood. Here, we conducted age-stratified genetic association studies against objectively measured (n = 62,276) or recalled childhood adiposity-related traits (neff = 599,924), identifying 624 com...
The results underscore the role of psychiatric genetic liability, beyond diagnosed psychiatric disorders, in contributing to both COVID-19 and other respiratory infection severity, and provide insights that may improve future risk stratification and public health strategies targeting respiratory viruses.
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