Author

O. Bechter

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Review Open access Oct 2026

CRISPR-based interrogation of alternative lengthening of telomeres: mapping dependencies, stress-buffering pathways, and therapeutic vulnerabilities.

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that supports the growth of approximately 5-10% of human tumors and represents an attractive but insufficiently explored therapeutic target. CRISPR-based functional genomics has emerged as a powerful approach to system...

Ruth Lannoo, O. Bechter, D. Daelemans · Cancer Letters · 0 citations

Open access Aug 2026

Mapping tumor microenvironment heterogeneity of human melanoma metastases across distant organs

A first multi-organ atlas of melanoma distant metastasis is provided allowing deeper understanding of how a melanoma is remodelled by, and/or remodels, three distinct human organ environments.

Carlos Ariel Pulido-Vicuña, Marek Piprek, Philip Georg Demaerel et al. · bioRxiv · 0 citations