The effect of diet on genetic regulation in humans remains largely unexplored. Here, we investigate gene-diet interactions in a unique group of healthy individuals (N = 200) who alternate between omnivory and dietary restriction of animal products for religious reasons. Using longitudinal proteomic and genotype data, w...
Alexandros Simistiras, O. Bocher, C. Emmanouil et al.· Nature Communications· 0 citations
Background Multi-omics integration has emerged as a powerful strategy to decode the molecular complexity of biological systems. However, the diversity of available methods, each designed with distinct assumptions, objectives, and computational requirements, makes method selection, usage and interpretation challenging f...
Iñigo Clemente-Larramendi, J. Gliozzo, Lourdes Velo-Suárez et al.· bioRxiv· 0 citations
These findings identify shared genetic loci between T2D and neurodegenerative dementia, revealing systemic metabolic-neurodegenerative trade-offs and highlighting key genes that underpin the comorbidity, providing a framework for improved understanding of age-related multi-morbidity.
A. Arruda, Archit Singh, O. Bocher et al.· HGG advances· 0 citations
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