O. Caffo

Enzalutamide-Induced Host Metabolic Reprogramming Is Associated with Treatment Outcomes in Patients with Castration-Resistant Prostate Cancer: A Hypothesis-Generating Study.

Host metabolic changes in response to drug treatment may shape individual pharmacological outcomes. This study aims to identify serum metabolomics signatures potentially associated with individual responses to enzalutamide treatment in metastatic castrate-resistant prostate cancer (mCRPC) patients. Targeted metabolomic...

The RNA cargo of plasma-derived extracellular vesicles in mCRPC patients captures cancer cells and tumor microenvironment signals

Circulating analytes in cancer patients capture tumor-related signals. We profiled matched extracellular vesicle (EV) total RNA and cell-free DNA (cfDNA) from the same plasma aliquots of chemo-naive metastatic castration-resistant prostate cancer (mCRPC) patients treated with Enzalutamide (n=54 patients, n=119 longitud...

Prognostic value of post-neoadjuvant pathological response and residual disease in early breast cancer: a real-world cohort study.

Beyond morphology: imaging the glioblastoma microenvironment in the era of quantitative neuro-oncology

Future research should prioritize harmonized multicenter studies and biologically informed multimodal analytical frameworks to enable the routine implementation of microenvironment-oriented precision imaging in GBM management.