Sep 2026
Empagliflozin shields brain from methotrexate toxicity: Nrf2/HO-1/GPX4 activation prevents ferroptosis and chemo-brain in rats.
BACKGROUND Methotrexate (MTX) can induce "chemo-brain," but mechanisms remain incompletely defined. Ferroptosis has been implicated in MTX toxicity. We investigated whether Empagliflozin (EMPA) protects against MTX-induced neurotoxicity by modulating ferroptosis-related pathways. METHODS Male Sprague-Dawley rats (n =...
Mohammad El-Nablaway, Hend M. Hassan, O. Erfan et al.
· Tissue & Cell · 0 citations