O. Foresto-Neto

Butyrate improves the metabolism of proximal tubular cells and attenuates tissue damage in oxalate-induced acute kidney injury.

Metabolic reprogramming of renal cells is closely linked to kidney injury and repair. In proximal tubular cells (PTCs), impaired mitochondrial and peroxisomal fatty acid oxidation leads to compensatory increase in glycolysis to meet energy demands. Short-chain fatty acids such as butyrate modulate cell metabolism and c...

Micro- and Nanoplastics in the Human Exposome: Environmental Pathways, Kidney Toxicity, and Implications for Public Health Risk Assessment

Plastic pollution has emerged as a global environmental and public health crisis, with micro- and nanoplastics (MNPs) representing a pervasive component of the human exposome. Generated through the continuous fragmentation of larger plastic materials, MNPs exhibit physicochemical properties that influence their environ...

HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation