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Open access Aug 2026

An Integrative Multimodal Model for Early Diagnosis of Dementia and Differential Diagnosis of Alzheimer's Disease Using Neuroimaging, Polygenic Risk, and Cognitive Assessments

Multimodal integration of cognitive, neuroimaging, and polygenic data in the MHS-RWD tool yields strong discrimination for both early diagnosis of dementia and AD differential diagnosis, which could support etiologically informed dementia decisions in real-world settings, with potential utility in primary care.

T. T. Filiz, V. Fominykh, K. Persson et al. · 0 citations
Open access Aug 2026

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.

Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al. · 0 citations

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