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Open access Sep 2026

577. **Rafaelsen Award Presentation** Association between cortical serotonin release and cognitive function in schizophrenia: an in vivo [11C]Cimbi-36 PET study with a d-Amphetamine challenge

Abstract Background Cognitive symptoms of schizophrenia are highly disabling. There are no licensed treatments and the underlying neurobiology is unclear. Indirect evidence implicates abnormalities in cortical serotonergic neurotransmission, but no prior study has tested if cortical serotonin release is associated with...

M. Osugo, T. R. Marques, M. Veronese et al. · 0 citations
Open access Sep 2026

Striatal dopaminergic function and cortical functional connectivity in 22q11.2 deletion syndrome: an integrative multimodal 18F-DOPA PET and magnetic resonance imaging study.

Dopaminergic signalling is critical for regulating large-scale brain network dynamics and is implicated in the pathophysiology of psychotic disorders. 22q11.2 deletion syndrome (22q11DS), a high-penetrance genetic risk factor for schizophrenia, is associated with both dopaminergic alterations and disruptions in functio...

V. Mancini, M. Rogdaki, S. Jauhar et al. · 0 citations

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