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Aug 2026

Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism.

Primary aldosteronism affects 5 to 20% of the hypertensive population and is associated with increased cardiovascular and metabolic risk compared with primary hypertension. Alterations in the dynamics of aldosterone secretion are key, but these are not well captured by current diagnostic pathways, and the disease is of...

M. Grytaas, T. Upton, Isabella Marinelli et al. · 1 citation
Open access Jul 2026

Tissue-specific clustering of genetic correlations across autoimmune diseases in a nationwide sibling study.

It is demonstrated that ADs share substantial cluster-specific genetic overlap that largely aligns with affected tissue types, leading to distinct groupings of connective tissue diseases, gastrointestinal disorders, and endocrinopathies, whereas diseases of the nervous system show limited genetic cohesion.

Daniel Eriksson, R. Kuja-Halkola, M. Holmqvist et al. · 0 citations

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