O. Kaplan

Metabolic impact of bisphenol A on retinal pigment epithelium: disturbed energy pathways and antioxidant response in ARPE-19 cells.

Bisphenol A (BPA) is a widely utilized endocrine-disrupting chemical that has been associated with metabolic dysregulation in various tissues. Nevertheless, its impact on ocular metabolism remains insufficiently understood. This study aims to investigate the metabolic effects of BPA exposure in ARPE-19 retinal pigment...

Metabolomic Fingerprints of L-PRP and P-PRP: Formulation differences and Storage-induced Shifts.

Development, Validation and Application of an RP-HPLC Method for the Determination of Reproxalap in Cyclodextrin Inclusion Complexes and an In Situ Ocular Hydrogel

Background/Objectives: The aim of this study was to develop and validate a simple, accurate, reproducible, and sensitive reverse-phase high-performance liquid chromatography method for the quantification of reproxalap (RP) in cyclodextrin (CD) inclusion complexes and poloxamer 407 hydrogel formulations. Methods: Chroma...

Difluoromethoxy-Substituted Hexahydroquinolines as Multi-Target Anti-Inflammatory Agents: Mechanistic and Metabolomic Insights

Abstract In this study, a series of 15 difluoromethoxy-substituted hexahydroquinoline (HHQ) derivatives were synthesized and evaluated for their anti-inflammatory potential. The cytotoxicity profiles of the synthesized compounds were assessed using the MTT assay in LPS-stimulated RAW 264.7 macrophages. At 10 μM, severa...

Plasma Metabolic Features Associated with Developmental Regression in Autism Spectrum Disorder: A Pilot Untargeted Metabolomics Study

Several plasma metabolic features showing abundance differences among children with REG+, REG−, and typically developing controls are identified and require confirmation using authenticated standards, targeted quantitative methods, and independently recruited cohorts before any diagnostic, predictive, or therapeutic re...