Atherosclerosis is an age-related immune-metabolic disease in which lipid retention, endothelial dysfunction, innate immune activation, and vascular remodeling interact over decades. In older adults, inflammaging, mitochondrial dysfunction, defective autophagy/mitophagy, and cellular senescence may lower the threshold...
Yelizaveta A. Marakhovskaya, Ksenia A. Eruslanova, O. Maltseva et al.· Biomolecules· 0 citations
Advances in understanding mitochondrial biology have enabled the development of novel therapeutic approaches, including activators of the PINK1/Parkin pathway, inhibitors of LRRK2 and α-synuclein aggregation, and strategies promoting mitochondrial biogenesis and intercellular transfer, offering potential for disease mo...
A. V. Poznyak, V. Pavshintsev, Aleksandra O. Utkina et al.· International journal of inn...· 0 citations
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