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Author

O. Ohara

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Open access Sep 2026

Human Monocytic Models Reveal Genotype-Dependent Inflammatory Programs in VEXAS Syndrome.

OBJECTIVES VEXAS syndrome is a severe X-linked autoinflammatory disorder caused by somatic mutations in ubiquitin-like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype-specific inflammatory programs and identify potential therapeutic targets. METHO...

K. Higashitani, T. Ban, Y. Kirino et al. · 0 citations
Open access Jul 2026

Enrichment-free deep proteomics enables proteome-scale analysis of methionine oxidation

Overall, this study established an enrichment-free framework for the proteome-scale methionine oxidation analysis, and demonstrated that integrating oxidation and expression data enables the spatially resolved interpretation of cellular redox states.

Hiromasa Mitsui, Yusei Okuda, R. Konno et al. · 0 citations
Open access Aug 2026

Disruption of de novo fatty acid biosynthesis rewires cellular lipid metabolism toward mTOR-associated compensatory fatty acid uptake

Integrative multi-omics analyses in EL4 T cells reveal unrecognized mechanisms of lipid metabolic adaptation and highlight a regulatory network that coordinates fatty acid uptake in response to impaired lipid synthesis.

Takeru Endo, T. Kanno, R. Konno et al. · 0 citations

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