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O. Oyeneyin

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Open access Oct 2026

Synthesis, characterization, X-ray diffraction, in silico studies and in vitro biological evaluation of acylthiourea-derived thiazole-2-imines

A series of thiazole-2-imines (1a–1f) with unsubstituted aryl groups or aryl groups bearing methyl, methoxy, fluoro, or nitro substituents was designed using selected structural features of thiamine as inspiration. The compounds were synthesized from monosubstituted acylthioureas and para-substituted phenacyl bromides...

E. Kangara, Thishana Singh, P. Khoza et al. · 0 citations
Open access Jul 2026

Computational design and AI driven discovery of anaplastic lymphoma kinase inhibitors for non small cell lung cancer treatment

Artificial intelligence and computational techniques employed to screen a library of ALK tyrosine kinase inhibitors, retrieved from ChEMBL database, suggest that briga_15 and crizo_35 are promising leads warranting further optimization, synthesis, and biological evaluation.

O. Oyeneyin, N. Ipinloju, N. Gumede · 0 citations

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