O. Perik-Zavodskaia

CoexpressDeconvolve enables reference-free single-cell-resolution deconvolution from spot-based spatial transcriptomics

Summary Spot-based spatial transcriptomics captures the transcriptome of multiple adjacent cells per spot, obscuring cell type-specific signals. Most deconvolution tools, therefore, depend on external single-cell references and return cell-type fractions rather than the number of cells, and only some output full expres...