Author

O. Ranzani

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Open access Aug 2026

1-Year follow-up evaluation of TAK-003 dengue vaccine effectiveness against symptomatic disease and hospitalisation in adolescents during the 2024–2025 outbreak in São Paulo, Brazil: a test-negative case-control study

Summary Background Dengue is a growing global health threat. Our initial evaluation of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo State, Brazil, showed short-term protection but suggested possible effectiveness waning after 90-days of the first dose, and had limited power to estimat...

Lisany Krug Mareto, Thiago Sanches Brumatti, Roberto Dias de Oliveira et al. · EClinicalMedicine · 0 citations

Review Open access Jul 2026

Predicting, describing, or measuring? How to align model purpose with validity and applicability in critical care outcome research.

PURPOSE OF REVIEW Clinical models are commonly applied in critical care for both descriptive and predictive purposes. However, methodological rigour is often lacking in their development and validation. This review examines the principles underlying the multiple domains of model validity. We argue that a clear model pu...

A. Tracy, Aasiyah Rashan, O. Ranzani · Current Opinion in Critical... · 0 citations