Antisense oligonucleotides (ASOs) are potent therapeutics that enable precise RNA modulation. However, efficient delivery to tissues and cell types remains a major challenge. Multimerization, linking multiple ASOs to form large constructs, represents a promising strategy to explore delivery and pharmacokinetics modul...
Quentin Vicentini, Elena Grobecker, D. Daniele et al.· Journal of Medicinal Chemist...· 0 citations
Introduction Cinacalcet (CINA), a Biopharmaceutics Classification System (BCS) Class IV drug, exhibits limited oral bioavailability due to poor aqueous solubility and low intestinal permeability. We aimed to mechanistically enhance the oral bioavailability of CINA through the development of advanced hybrid-stabilized n...
Rawan Gamal Eldin, Salma M. Mosleh, O. Saher et al.· Frontiers in Pharmacology· 2 citations
It is demonstrated that lipid identity critically determines ASO efficacy, productive cellular uptake, and regional CNS engagement, emphasizing the need for context-specific lipid design in ASO therapeutic development.
S. Roudi, H. Y. Estupiñán, O. Saher et al.· bioRxiv· 0 citations
The importance of formulation optimization in improving nucleic acid delivery is highlighted and practical insights for enhancing peptide- and lipid-based therapeutic platforms are provided.
D. Daniele, Z. Hein, O. Saher et al.· International Journal of Pha...· 0 citations
The kidney plays a critical role in metabolite excretion, fluid regulation, and homeostasis, yet remains highly vulnerable to structural and functional disorders. Kidney diseases represent a major global health burden, often progressing to chronic complications due to the limited efficacy and poor selectivity of conven...
Sadek Ahmed, Rana M. ElBishbishy, Mohamed A. Sadek et al.· Journal of Pharmacy & Pharma...· 4 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
