Author

O. Seifert

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Open access Sep 2026

The FAP × CD3 bispecific antibody OMTX305 induces T cell–mediated antitumor effects in patient-derived ex vivo models of solid tumors

Within solid tumors, stromal barriers and immune exclusion limit the success of immunotherapies. Thus, novel therapeutic approaches are required to remodel the tumor-supportive microenvironment and enhance therapeutic responses. We developed a bispecific, trivalent Fab-eIg T cell engager (OMTX305) targeting fibroblast...

Julia Thiel, Jan A. Schlegel, Chun-Guang Liang et al. · Science Advances · 0 citations

Review Open access Jul 2026

Protein engineering: status report

Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.

H. Ai, Frances H. Arnold, Doug Barrick et al. · Protein engineering, design... · 0 citations