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Author

O. Swann

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Open access Sep 2026

Plasma immune signatures associate with neurodegeneration in frontotemporal lobar degeneration

Plasma multiplex proteomics identified complementary dimensions of neuroaxonal injury and immune dysregulation across frontotemporal lobar degeneration-related syndromes and candidates for independent biomarker validation and mechanistic investigation are identified.

M. van Schaik, K. O. Lai, N. Shapiro et al. · 0 citations
Open access Aug 2026

Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing.

Multiple plasma proteins are elevated in presymptomatic and symptomatic ADAD mutation carriers relative to non-carriers, and combining biomarkers may help in staging presymptomatic AD and optimise clinical trial inclusion.

C. Belder, A. Heslegrave, O. Swann et al. · 1 citation
Open access Jul 2026

The neuropathy-causing GARS1ΔETAQ mutation drives pathology in subsets of motor and sensory neurons in mice

Together, these experiments show that GarsΔETAQ/+ mice display robust and selective peripheral nerve pathology that manifests in a general distal-to-proximal fashion, priming this CMT2D allele for testing treatments and evaluating mechanisms underlying peripheral nerve vulnerability.

R. Simkin, A. Paulo-Ramos, Qiuhan Lang et al. · 0 citations

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